Nonsedating antihistamine


In patients with seasonal allergic rhinitis and concomitant asthma, desloratadine treatment was also associated with significant reductions in total asthma symptom score and use of inhaled β-agonists.Use of desloratadine in patients with chronic idiopathic urticaria was associated with significant reductions in pruritus, number of hives, size of the largest hive, and interference with sleep and daily activities.Side effects of antihistamines depend in part on the specific type.The most common potential side effects include headache, digestive problems, aching muscles and fatigue.Although pharmaceutical manufacturers describe some of their products as non-sedating antihistamines, some patients do experience drowsiness, fatigue, impaired motor responses and concentration difficulties when taking them.On the other hand, some patients experience none of these symptoms when taking sedating antihistamines.Clinical experience in over 2300 patients has shown that the adverse event profile of desloratadine is similar to that of placebo; desloratadine has no clinically relevant effects on electrocardiographic parameters, does not impair wakefulness or psychomotor performance, and does not exacerbate the psychomotor impairment associated with alcohol use.Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are mostly used to treat allergies or cold and flu symptoms, although some first-generation antihistamines may also be used for other conditions.

Many types of antihistamines are available without a prescription.Examples of over-the-counter non-sedating antihistamines include the brand names Claritin®, Allegra®, and Zyrtec®.Most are available as just an antihistamine or in combination with other drugs such as decongestants.When the body comes into contact with something to which it is allergic, whether through contact, respiration or consumption, substances called histamines are released to attack the allergen.Histamines encourage the body to rid itself of the allergen by triggering ways to flush the allergen, such as watery eyes, a runny nose and sneezing; if the skin is the affected area, the histamines may produce a rash as protection.Prescription non-sedating antihistamines include Clarinex® tablets and the nasal spray, Astelin®.

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